环境毒理学研究室基于海外引进团队始建13年，历经成长、分化和再扩员，现有成员7人，其中教授2人，副教授3人，青年教师2人，博士生导师2人，硕士生导师5人。目前在站博士后2人，在读博士研究生7人，硕士研究生35人。研究室长期致力于环境应激的健康效应及机制研究，主要研究方向包括: (1)代谢性疾病发病机制及防治策略和方法研究，(2) 环境氧化应激与慢性病发生发展的关系及机制研究; (3)适应性抗氧化反应调控机制及应用研究;(4)计算毒理学方法及应用研究。近年发表高水平学术论文 (中科院II区及以上) 30余篇。研究团队先后获得国家自然科学基金重点和国际合作重点项目等9项、博士后特别资助和国际交流引进项目各1项，省部级课题等8项。具体项目信息如下：

1.国际（地区）合作与交流项目：糖尿病背景下镉暴露的肾脏毒性及Nrf2的时空特异性保护作用。项目编号：820201080272021.01-2025.12；直接经费：247万元。

2.辽宁省重点研发指导计划项目：以氧化-还原稳态调控为基础建立糖尿病及其并发症防治策略及方法。项目编号：2019JH8/10300012；2020.01-2021.12；直接经费：30万元。

3.国家自然科学基金重点项目：慢性饮水型砷暴露对2型糖尿病的促发机制以及评价和防治方法研究。项目编号：81830099；2019.01-2023.12；直接经费：294万元。

4.科技部“重大慢性非传染性疾病防控研究”重点专项（子课题1负责人）：东北地区重大慢病防控科技综合示范研究。项目编号：YFC1311600 2018.01-2020.12；专项经费：209万元。

5.国家自然科学基金面上项目：CNC-bZIP转录因子NRF1在砷致白色脂肪细胞新生及功能障碍中的作用机制研究。项目编号：81573106；2016.01-2019.12；直接经费：65万元。

1.国际（地区）合作与交流项目：糖尿病背景下镉暴露的肾脏毒性及Nrf2的时空特异性保护作用。项目编号：820201080272021.01-2025.12；直接经费：247万元。

2.辽宁省重点研发指导计划项目：以氧化-还原稳态调控为基础建立糖尿病及其并发症防治策略及方法。项目编号：2019JH8/10300012；2020.01-2021.12；直接经费：30万元。

3.国家自然科学基金重点项目：慢性饮水型砷暴露对2型糖尿病的促发机制以及评价和防治方法研究。项目编号：81830099；2019.01-2023.12；直接经费：294万元。

4.科技部“重大慢性非传染性疾病防控研究”重点专项（子课题1负责人）：东北地区重大慢病防控科技综合示范研究。项目编号：YFC1311600 2018.01-2020.12；专项经费：209万元。

5.国家自然科学基金面上项目：CNC-bZIP转录因子NRF1在砷致白色脂肪细胞新生及功能障碍中的作用机制研究。项目编号：81573106；2016.01-2019.12；直接经费：65万元。

6.美国国立环境健康科学研究院“杰出青年基金” (NIEHS-ONES Award): Paradoxical roles of Nrf2 activation in arsenic-induced beta-cell dysfunction. 2008-2014年；250万美元。

7.英国联合利华-安全与环境评价中心研究基金（子课题）：Nrf2 pathway mapping in human keratinocytes. 2013年；10万美元。

8.“亨丁顿舞蹈症”基金会-杜克大学-哈姆纳合作课题（子课题）：Characterization of the effects of “CHDI-compounds” on Nrf2/Nrf1-ARE activity. 2013年；3.9万美元。

9.美国化学工业协会基金 （子课题）： Determination and computational modeling of Nrf2 pathway. 2009-2011 年；30万美元。

10.美国国立糖尿病消化系及肾疾病研究所青年基金 (NIDDK-K01 Award): Paradoxical roles of reactive oxygen species in pancreatic beta-cell function。2007-2010年；41万美元。

11.美国化学工业协会基金 （子课题）：Activation of Nrf2-mediated oxidative stress response by hypochlorous acid. 2007-2009年；30万美元。

12.国家自然科学基金青年基金: 慢性砷暴露对内源性一氧化氮代谢和功能的影响。2001-2003年；15万元。化氮代谢和功能的影响

1. Chen C, Zhou Z, Yu S, Ma Y, Wang G, Han X, Jiao C, Luan J, Liu Z, Xu Y, Wang H, Zhang Q, Fu J, Zhou H*, Pi J*. Nrf2 protects against renal fibrosis induced by chronic cadmium exposure in mice. Food Chem Toxicol. 2023 Jun 5;178:113875. IF=4.3

2. Liu Z, Deng P, Liu S, Bian Y, Xu Y, Zhang Q, Wang H*, Pi J*. Is Nuclear Factor Erythroid 2-Related Factor 2 a Target for the Intervention of Cytokine Storms? Antioxidants (Basel). 2023 Jan 11;12(1):172. IF=7.0

3. Wang H, Zhang Q, Pi J. Advances in research strategies and approaches for toxicity testing of environmental exposures. Toxicol Appl Pharmacol. 2023 Feb 1; 460:116363. IF=3.8

4. Deng T, Xu X, Fu J, Xu Y, Qu W, Pi J*, Wang H*. Application of ARE-reporter systems in drug discovery and safety assessment. Toxicol Appl Pharmacol. 2022 Nov 1; 454:116243. IF=3.8

5. Jin Q, Yao C, Bian Y*, Pi J*. Pb-induced eryptosis may provoke thrombosis prior to hemolysis. International Journal of Molecular Sciences. 2022.23:7008.  IF=5.6

6. Liu S, Pi J*, Zhang Q*. Signal amplification in the KEAP1-NRF2-ARE antioxidant response pathway. Redox Biology.2022 Aug;54:102389. IF=11.4

7. Luan J, Fu J, Jiao C, Hao X, Feng Z, Zhu L, Zhang Y, Zhou G, Li H, Yang W, Yuen PST, Kopp JB, Pi J*, Zhou H*. IL-18 deficiency ameliorates the progression from AKI to CKD. Cell Death Dis. 2022 Nov 15;13(11):957. IF=9.0

8. Liu Z, Wang H, Hou Y, Yang Y, Jia J, Wu J, Zuo Z, Gao, Ren S, Bian Y, Liu S, Fu J, Sun Y, Li J, Masayuki Yamamoto, Zhang Q, Xu Y*, Pi J*. CNC-bZIP protein NFE2L1 regulates osteoclast differentiation in antioxidant-dependent and independent manners. Redox Biology. 2021 Nov 6; 48:102180. IF=10.787

9. Bao S, Zheng H, Chen C, Zhang Y, Bao L, Yang B, Hou Y, Chen Y, Zhang Q, Pi J*, Fu J*. Nfe2l1 deficiency mitigates streptozotocin-induced pancreatic β-cell destruction and development of diabetes in male mice. Food Chem Toxicol. 2021 Oct 23;112633. IF=5.572

10. Liu S, Pi J*, Zhang Q*. Mathematical modeling reveals quantitative properties of KEAP1-NRF2 signaling. Redox Biology. 2021 Nov;47:102139. IF=10.787

11. Bian Y, Chung HY, Bae ON, Lim KM, Chung JH*, Pi J*. Titanium dioxide nanoparticles enhance thrombosis through triggering the phosphatidylserine exposure and procoagulant activation of red blood cells. Part Fibre Toxicol. 2021 Aug 4;18(1):28. IF=9.112 

12. Yin Y, Peng H, Shao J, Zhang J, Li Y, Pi J*, Guo J*. NRF2 deficiency sensitizes human keratinocytes to zinc oxide nanoparticles-induced autophagy and cytotoxicity. Environ Toxicol Pharmacol. 2021 Jul 30;103721. IF=5.785

13. Sun J, Hong Z, Shao S, Li L, Yang B, Hou Y, Wang H, Xu Y, Zhang Q, Pi J*, Fu J*. Liver-specific Nrf2 deficiency accelerates ethanol-induced lethality and hepatic injury in vivo. Toxicol Appl Pharmacol. 2021 Jun 8;115617. IF=4.46

14. Xu Y*, Tokar EJ*, Pi J*. Arsenic as an environmental toxicant and a therapeutic agent: Foe and friend. Toxicol Appl Pharmacol. 2021 Mar 15; 415:115438. Epub 2021 Feb 4 .IF=4.46

15. Wang Z, Hou Y, Ren S, Liu Z, Zuo Z, Huang S, Wang W, Wang H, Chen Y, Xu Y, Masayuki Yamamoto, Zhang Q, Fu J*, Pi J*. CL316243 treatment mitigates the inflammation in white adipose tissues of juvenile adipocyte-specific Nfe2l1 knockout mice. Free Radic Biol Med. 2021 Feb 3; 165:289-298. IF=8.101

16. Ding H, Jiang M, Li D, Zhao Y, Yu D, Zhang R, Chen W, Pi J*, Chen R, Cui L, Zheng Y, Piao J*. Effects of Real-Ambient PM Exposure on Lung Damage Modulated by Nrf2. Front Pharmacol. 2021 Apr 23; 12:662664. IF=5.988

17. Gao T, Lai M, Zhu X, Ren S, Yin Y, Wang Z, Liu Z, Zuo Z, Hou Y, Pi J*, Chen Y *. Rifampicin impairs adipogenesis by suppressing NRF2-ARE activity in mice fed a high-fat diet. Toxicol Appl Pharmacol. 2021 Jan 4; 413:115393. doi: 10.1016/j.taap.2020.115393. IF=4.46

18. Chen C, Han X, Wang G, Liu D, Bao L, Jiao C, Luan J, Hou Y, Xu Y, Wang H, Zhang Q, Zhou H, Fu J*, Pi J*. Nrf2 defciency aggravates the kidney injury induced by subacute cadmium exposure in mice. Archives of Toxicology.2021 Jan 04. Doi:10.1007/s00204-020-02964-3. IF=6.168

19. Ren S, Hou Y, Zuo Z, Liu Z, Wang H, Xu Y, Yamamoto M, Zhang Q, Fu J*, Pi J*. Protracted rosiglitazone treatment exacerbates inflammation in white adipose tissues of adipocyte-specific Nfe2l1 knockout mice. Food Chem Toxicol. 2020 Nov 1; 146:111836. doi: 10.1016/j.fct.2020.111836. IF=6.023  

20. Cui X, Fu J, Luan J, Qi H, Jiao C, Ran M, Wang D, Hao X, Zhang Y, Kopp JB, Pi J*, Zhou H*. CircZNF609 is involved in the pathogenesis of focal segmental glomerulosclerosis by sponging miR-615-5p. Biochem Biophys Res Commun. 2020 Aug 13; (20):31455-8. IF=3.575

21. Lyu H, Wang H, Li L, Zhu J, Chen F, Chen Y, Liu C1, Fu J, Yang B, Zhang Q, Xu Y*, Pi J*. Hepatocyte-specific deficiency of Nrf2 exacerbates carbon tetrachloride-induced liver fibrosis via aggravated hepatocyte injury and subsequent inflammatory and fibrogenic responses. Free Radic Biol Med. 2020; 150:136-147. IF=7.376

22. Li L, Fu J, Liu D, Sun J, Hou Y, Chen C, Shao J, Wang L, Wang X, Zhao R, Wang H, Andersen ME, Zhang Q, Xu Y*, Pi J*. Hepatocyte-specific Nrf2 Deficiency Mitigates High-Fat Diet-Induced Hepatic Steatosis: Involvement of Reduced PPARγ Expression. Redox Biol. 2020; 30:101412. IF=11.799

23. Xue P, Hou Y, Zuo Z, Wang Z, Ren S, Dong J, Fu J, Wang H, Andersen ME, Zhang Q, Xu Y∗, Pi J∗. Long Isoforms of NRF1 Negatively Regulate Adipogenesis via Suppression of PPARγ Expression. Redox Biol. 2020; 30:1014 IF=11.799

24. Qi H, Fu J, Luan J, Jiao C, Cui X, Cao X, Zhang Y, Wang Y, Kopp JB, Pi J*, Zhou H*. miR-150 inhibitor ameliorates adriamycin-induced focal segmental glomerulosclerosis. Biochem Biophys Res Commun. 2020; 522:618-625. IF=3.575

25. Luan J, Fu J, Chen C, Jiao C, Kong W, Zhang Y, Chang Q, Wang Y, Li D, Illei GG, Kopp JB, Pi J*, Zhou H*, LNA-anti-miR-150 ameliorated kidney injury of lupus nephritis by inhibiting renal fibrosis and macrophage infiltration. Arthritis Res Ther. 2019; 2019; 21:276. IF=4.103

26. Zuo Z, Liu Z, Gao T, Yin Y, Wang Z, Hou Y*, Fu J, Liu S, Wang H, Xu Y, Pi J*. Prolonged inorganic arsenic exposure via drinking water impairs brown adipose tissue function in mice. Sci Total Environ. 2019; 668:310-317.IF =6.551

27. Liu Z, Hou Y, Li L, Yang Y, Jia J, Hong Z, Li T, Xu Y, Fu J, Sun Y, Yamamoto M, Wang H*, Pi J*. Nrf2 deficiency aggravates the increase in osteoclastogenesis and bone loss induced by inorganic arsenic. Toxicol Appl Pharmacol. 2019; 367:62-70. IF=3.347

28. Li L, Fu J*, Sun J, Liu D, Chen C, WangH, Hou Y, Xu Y, Pi J*. Is Nrf2-ARE a potential target in mitigation of non-alcoholic fatty liver disease? Current Opinion in Toxicology. 2019; 13:35–44. IF= 0.877

29. Pi J#, Hayes JD, Yamamoto M. New Insights into Nuclear factor erythroid 2-related factors in Toxicology and Pharmacology. (Editorial) Toxicol Appl Pharmacol. 2019; 367:33-35 IF= 3.347

30. Zhu J, Wang H*, Chen F, Lv H, Xu Z, Fu J, Hou Y, Xu Y, Pi J*. Triptolide enhances chemotherapeutic efficacy of antitumor drugs in non-small-cell lung cancer cells by inhibiting Nrf2-ARE activity. Toxicol Appl Pharmacol. 2018; 58:1-9. IF= 3.585

31. Sun J, Fu J*, Li L, Chen C, Wang H, Hou Y, Xu Y, Pi J*. Nrf2 in alcoholic liver disease. Toxicol Appl Pharmacol. 2018; 57:62-69. IF= 3.585

32. Sun J, Fu J*, Zhong Y, Li L, Chen C, Wang X, Wang L, Hou Y, Wang H, Zhao R, Zhang X, Yamamoto M, Xu Y, Pi J*. NRF2 mitigates acute alcohol-induced hepatic and pancreatic injury in mice. Food Chem Toxicol. 2018; 21:495-503. IF= 3.775

33. Hou Y, Liu Z, Zuo Z, Gao T, Fu J, Wang H, Xu Y, Liu D, Yamamoto M, Zhu B, Zhang Y, Andersen ME, Zhang Q, Pi J*. Adipocyte-specific deficiency of Nfe2l1 disrupts plasticity of white adipose tissues and metabolic homeostasis in mice. Biochem Biophys Res Commun. 2018; 3:264-270. IF= 2.705

34. Wang H, Zhu J, Liu Z, Lv H, Lv P, Chen F, Fu J, Hou Y, Zhao R, Xu Y, Zhang Q, Pi J*. Silencing of long isoforms of Nuclear factor erythroid 2-related factor 1 primes macrophages towards M1 polarization. Free Radic Biol Med. 2018；117:37-44. IF=5.567.

35. Kong W, Fu J, Liu N, Jiao C, Guo G, Luan J, Wang H, Yao Y, Wang L, Yamamoto M, Pi J*, Zhou H*. Nrf2 deficiency promotes the progression from acute tubular damage to chronic renal fibrosis following unilateral ureteral obstruction. Nephrol Dial Transpl. 2018; 33:771-783. IF=4.198.

36. Fu J, Zheng H, Cui Q, Chen C, Bao S, Sun J, Li L, Yang B, Wang H, Hou Y, Xu Y, Xu Y, Zhang Q, Pi J*. Nfe2l1 silenced insulinoma cells acquire aggressiveness and chemo-resistance. Endocr Relat Cancer. 2017; pii: ERC-17-0458. doi: 10.1530/ERC-17-0458. IF=4.774.

37. Wang H, Zhu J, Li L, Li Y, Lv H, Xu Y, Sun G, Pi J*. Effects of Nrf2 deficiency on arsenic metabolism in mice. Toxicol Appl Pharmacol. 2017; 37:111-119. IF=3.616.

38. Chen F, Wang H, Zhu J, Zhao R, Xue P, Zhang Q, Nelson MB, Qu W, Feng B*, Pi J*. Camptothecin suppresses NRF2-ARE activity and sensitizes hepatocellular carcinoma cells to anticancer drugs. Br J Cancer. 2017; 117:1495-1506. IF=5.922

39. Cui Q, Fu J*, Hu Y, Li Y, Yang B, Li L, Sun J, Chen C, Sun G, Xu Y, Zhang Q, Pi J*. Deficiency of long isoforms of Nfe2l1 sensitizes MIN6 pancreatic β cells to arsenite-induced cytotoxicity. Toxicol Appl Pharmacol. 2017; 329:67-74. IF=3.616

40. Fu J, Cui Q, Yang B, Hou Y, Wang H, Xu Y, Wang D, Zhang Q, Pi J*. The impairment of glucose-stimulated insulin secretion in pancreatic β-cells caused by prolonged glucotoxicity and lipotoxicity is associated with elevated adaptive antioxidant response. Food Chem Toxicol. 2017; 100:161-167. IF=4.946

41. Wu R, Wu X, Wang H, Fang X, Li Y, Gao L, Sun G, Pi J*, Xu Y*. Strain differences in arsenic-induced oxidative lesion via arsenic biomethylation between C57BL/6J and 129X1/SvJ mice. Sci Rep. 2017 Mar 17; 7:44424. doi: 10.1038/srep44424. IF=4.0

42. Zhu J, Wang H, Chen F, Fu J, Xu Y*, Hou Y, Kou HH, Zhai C, Zhang Q, Andersen ME, Pi J*. An overview of chemical inhibitors of the Nrf2-ARE signaling pathway and potential applications in cancer therapy. Free Radic Biol Med. 2016; 99: 544-556. IF=5.606

43. Fu J, Hou Y, Xue P, Wang H, Xu Y, Qu W, Zhang Q, Pi J*. Nrf2 in Type 2 diabetes and diabetic complications: Yin and Yang. Current Opinion in Toxicology. 2016; 1:9-19.

44. Chen Y, Xu Y*, Zheng H, Fu J, Hou Y, Wang H, Zhang Q, Yamamoto M, Pi J*. The role of nuclear factor E2-Related factor 2 and uncoupling protein 2 in glutathione metabolism: Evidence from an in vivo gene knockout study. Biochem Biophys Res Commun. 2016; 478:87-92.

45. Peng H, Wang H, Xue P, Hou Y, Dong J, Zhou T, Qu W, Peng S, Li J, Carmichael PL, Nelson B, Clewell R, Zhang Q, Andersen ME, Pi J*. Suppression of NRF2-ARE activity sensitizes chemotherapeutic agent-induced cytotoxicity in human acute monocytic leukemia cells. Toxicol Appl Pharmacol. 2016; 292:1-7.

46. Zheng H, Fu J, Xue P, Zhao R, Dong J, Liu D, Yamamoto M, Tong Q, Teng W*, Qu W, Zhang Q, Andersen ME, Pi J*. CNC-bZIP protein Nrf1-dependent regulation of glucose-stimulated insulin secretion. Antioxid Redox Signal. 2015; 22:819-31.

47. Fu J, Zheng H, Wang H, Yang B, Zhao R, Lu C, Liu Y, Hou Y, Xu Y, Zhang Q, Qu W, Pi J*. Protective role of nuclear factor E2-related factor 2 against acute oxidative stress-induced pancreatic β-cell damage. Oxidative Med and Cellular Longevity. 2015; Article ID 639191.

48. Pi J*, Zhang Q, Andersen ME. ROS and antioxidants in pancreatic β-cell function: Yin and Yang. (Book chapter). Systems biology of free radicals and anti-oxidants. Springer-Verlag Berlin Heidelberg. 2014; DOI 10.1007/978-3-642-30018-9_159.

49. Chen Y, Xue P, Hou Y, Zhang H, Zheng H, Zhou T, Qu Q, Teng W*, Zhang Q, Andersen ME, Pi J*. Isoniazid suppresses antioxidant response element activities and impairs adipogenesis in mouse and human preadipocytes. Toxicol Appl Pharmacol. 2013; 273: 435-441.

50. Lv P, Xue P, Dong J, Peng H, Clewell R, Wang A, Wang Y, Peng Q, Qu W, Zhang Q, Andersen ME, Pi J*. Keap1 silencing boosts lipopolysaccharide-induced transcription of interleukin 6 via activation of nuclear factor κB in macrophages. Toxicol Appl Pharmacol. 2013; 272:697-702.

51. Fu J, Zhang Q, Woods CG, Zheng H, Yang B, Qu W, Andersen ME, Pi J*. Divergent effects of sulforaphane on basal and glucose-stimulated insulin secretion in β-cells: role of reactive oxygen species and induction of endogenous antioxidants. Pharmaceutical Res. 2013; 30:2248–2259.

52. Xue P, Hou Y, Chen Y, Yang B, Fu J, Zheng H, Yarborough K, Woods CG, Liu D, Collins S, Yamamoto M, Zhang Q, Andersen ME, Pi J*. Adipose deficiency of Nrf2 in ob/ob mice results in severe metabolic syndrome. Diabetes. 2013; 62:845-854.

53. Hou Y, Xue P, Woods CG, Wang X, Fu J, Yarborough K, Qu W, Zhang Q, Andersen ME, Pi J*. Association between arsenic suppression of adipogenesis and induction of CHOP10 via the endoplasmic reticulum stress response. Environ. Health Perspect. 2013; 121:237-243.

54. Yang B, Fu J, Zheng H, Xue P, Yarborough K, Woods CG, Hou Y, Zhang Q, Andersen ME, Pi J*. Deficiency in the nuclear factor E2-related factor 2 renders pancreatic β-cells vulnerable to arsenic-induced cell damage. Toxicol Appl Pharmacol. 2012; 264:315-323.

55. Zhan L, Zhang H, Zhang Q*, Woods CG, Chen Y, Xue P, Dong J, Tokar EJ, Xu Y, Hou Y, Fu J, Yarborough K, Wang A, Qu W, Waalkes MP, Andersen ME, Pi J*. Regulatory role of KEAP1 and NRF2 in PPARγ expression and chemoresistance in human non-small cell lung carcinoma cells. Free Radic Biol Med. 2012; 53:758-768.

56. Zhao R, Hou Y, Zhang Q, Woods CG, Xue P, Fu J, Yarborough K, Guan D, Andersen ME, Pi J*. Cross-regulations among NRFs and KEAP1 and effects of their silencing on arsenic-induced antioxidant response and cytotoxicity in human keratinocytes. Environ. Health Perspect. 2012; 4:583-589.

57. Hou Y, Xue P, Bai Y, Liu D, Woods CG, Yarborough K, Fu J, Zhang Q, Sun G, Collins S, Chan JY, Yamamoto M, Andersen ME, Pi J*. Involvement of nuclear factor E2-related factor 2 in transcriptional regulation of CCAAT/enhancer-binding protein β expression in the early stage of adipogenesis. Free Radic Biol Med. 2012; 52:462-472.

58. Xue P, Hou Y, Zhang Q, Woods CG, Yarborough K, Liu H, Sun G, Andersen ME, Pi J*. Prolonged inorganic arsenite exposure suppresses insulin-stimulated AKT S473 phosphorylation and glucose uptake in 3T3-L1 adipocytes: Involvement of the adaptive antioxidant response. Biochem Biophys Res Commun. 2011; 407: 360-365.

59. Zhao R, Hou Y, Xue P, Woods CG, Fu J, Feng B, Guan D, Sun G, Chan JY, Waalkes WP, Andersen ME, Pi J*. Long isoforms of NRF1 contribute to arsenic-induced antioxidant response in human keratinocytes. Environ. Health Perspect. 2011; 119: 56-62.

60. Pi J#, *, Leung L#, Xue P, Wang W, Hou Y, Liu D, Yehuda-Shnaidman E., Lee C, Lau J, Kurtz TW, Chan JY*.  Deficiency in the nuclear factor E2-related factor 2 transcription factor results in impaired adipogenesis and protects against diet-induced obesity. J Biol Chem. 2010; 285:9292-300.

61. Fu J, Woods CG, Yehuda-Shnaidman E., Zhang Q, Wong V, Collins S, Sun G, Andersen ME, Pi J*. Arsenic impairs glucose-stimulated insulin secretion in pancreatic beta-cells: involvement of Nrf2-mediated antioxidant response. Environ. Health Perspect. 2010; 118:864-870.

62. Pi J* and Collins S*. ROS and UCP2 in pancreatic β-cell function. Diabetes Obes. Metab. 2010; 12S2:141-148.

63. Pi J*, Freeman ML, Yamamoto M. Nrf2 in toxicology and pharmacology: the good, the bad and the ugly? (Editorial) Toxicol Appl Pharmacol. 2010; 244: 1-3.

64. Pi J#, *, Zhang Q, Fu J, Woods CG, Collins S, Andersen ME. ROS signaling and oxidative stress in pancreatic beta-cell function. Toxicol Appl Pharmacol. 2010; 244:77-83.

65. Woods CG, Fu J, Pluta L, Yang L, Zhang Q, Thomas RS, Mckee RH, Andersen ME, Pi J*. Dose-dependent transitions in Nrf2-mediated adaptive response and related stress responses to hypochlorous acid in mouse macrophages. Toxicol Appl Pharmacol. 2009; 238:27-29.

66. Pi J*, Bai Y, Daniel K, Dianxin Liu, Edelstein D, Brownlee M, Corkey BE, Collins S*. Persistent oxidative stress due to absence of UCP2 associated with impaired pancreatic beta-cell function. Endocrinology. 2009; 150:3040-3048.

67. Pi J*, Diwan BA, Qu W, Liu J, Sun Y, MiroslavStyblo, Waalkes MP*. Arsenic-induced malignant transformation of human keratinocytes: involvement of Nrf2. Free Radic Biol Med. 2008; 45:651-658.

68. Pi J*, Zhang Q, Wong V, Woods C, Collins S, Andersen ME. Activation of Nrf2-mediated oxidative stress response in macrophages by hypochlorousacid.Toxicol Appl Pharmacol. 2008; 226:236-43.

69. Pi J#, *, Bai Y, Zhang Q, Floering LM, Wong V, Daniel K, Reece JM, Deeney JT, Corkey BE, Collins S. Reactive oxygen species as a signal in glucose-stimulated insulin secretion. Diabetes. 2007; 56:1783-1791.

70. Pi J#, *, Bai Y, Reece JM, William J, Liu D, Freeman ML, Fahl WE, Shugar D, Liu J, Qu W, Collins S, Waalkes MP. Molecular mechanism of Nrf2 activation and degradation: role of sequential phosphorylation by protein kinase CK2. Free Radic Biol Med. 2007; 42:1797-806.

71. Pi J#, Yamauchi H, Sun G, Yoshida T, Aikawa H, Fujimoto W, Iso H, Cui R, Waalkes MP, Kumagai Y. Vascular dysfunction in patients with chronic arsenosis can be reversed by reduction of arsenic exposure. Environ. Health Perspect. 2005; 113:339-341.

72. Pi J#, He Y, Bortner C, Huang J, Liu J, Zhou T, Qu W, North SL, Kasprzak KS, Diwan BA, Chignell CF, Waalkes MP. Low level, long-term inorganic arsenite exposure causes generalized resistance to apoptosis in cultured human keratinocytes: potential roles in skin co-carcinogenesis. Int J Cancer. 2005; 116:20-26.

73. Pi J#, Qu W, Reece JM, Kumagai Y, Waalkes MP. Transcription factor Nrf2 activation by inorganic arsenic in cultured keratinocytes: Involvement of hydrogen peroxide. Exp Cell Biol. 2003; 290:234-245.

74. Pi J#, Horikuchi S, Sun Y, Nikaido M, Shimojo N, Hayashi T, Yamauchi H, Itoh K, Yamamoto M, Sun G, Waalkes MP, Kumagai Y. A potential mechanism for the impairment of nitric oxide formation caused by prolonged oral exposure to arsenate in rabbits. Free Radic Biol Med. 2003; 35:102-13.

75. Pi J#, Yamauchi H, Kumagai Y, Sun G, Yoshida T, Aikawa H, Hopenhayn-Rich C, Shimojo N. Evidence for induction of oxidative stress caused by chronic exposure of Chinese residents to arsenic contained in drinking water. Environ. Health Perspect. 2002; 110:331-336.

76. Pi J#, Kumagai Y, Shimojo N. Improved method for simultaneous determination of L-arginine and its mono- and dimethylated metabolites in biological samples by high-performance liquid chromatography. J Chromatogr B. 2000; 742:199-203.

77. Pi J#, Kumagai Y, Sun G, Yamauchi H, Yoshida T, Iso H, Endo A, Yu L, Yuki K, Miyauchi T, Shimojo N. Decreased serum concentrations of nitric oxide metabolites among Chinese in an endemic area of chronic arsenic poisoning in Inner Mongolia. Free Radic Biol Med. 2000; 28:1137-42.

78. Pi J#, Yamauchi H, Kumagai Y, Sun G, Yoshida T, Aikawa H, Hopenhayn-Rich C, Shimojo N. Evidence for induction of oxidative stress caused by chronic exposure of Chinese residents to arsenic contained in drinking water. Environ Health Perspect. 2002 Apr;110(4):331-6.

在岗

中国医科大学公共卫生学院

2023：辽宁省优秀导师团队

2022：辽宁省优秀学位论文指导教师

2022：辽宁省教育成果奖 二等奖

2019.01：辽宁省外专百人计划人选

2018-2020：沈阳市领军人才

2015：辽宁省第二批“十百千工程”“百人”层次人选

2014：辽宁省人民政府 辽宁友谊奖

2013：辽宁省高等学校攀登学者