在研课题：辽宁省应用基础研究计划项目，“基于核心家系的外显子组测序联合定向软骨细胞分化模型鉴定发育性髋关节发育不良新致病基因”，2023.01-2025.12。

（近5年）

1.     辽宁省应用基础研究计划项目，“基于核心家系的外显子组测序联合定向软骨细胞分化模型鉴定发育性髋关节发育不良新致病基因”，2023.01-2025.12，30万元

2.     国家自然科学基金，81772296，“KANSL1基因在发育性髋关节发育不良发病中的作用及分子机制研究”，2018.01-2021.12，55万元

3.     国家自然科学基金，81371918，“PAPPA2基因在发育性髋关节发育不良发病机制中的作用研究”，2014.01-2017.12，70万元

4.     辽宁省教育厅重点实验室基础研究项目，LZ2014036,“小儿髋脱位遗传病因学的初步研究”，2014.01-2017.12，20万元

1. 授权专利（近5年）：

实用新型专利：一种可调式骨折复位器械，专利号：ZL 2021 2 0157627.3，授权公告日：2021.12.10

2. 出版专著（近5年）：

国家卫生健康委员会“十三五”规划教材《小儿外科学》第三版，编委，人民卫生出版社，2021.1

3. 出版文章（近5年）：

1.       Li, CY; Zhou, WZ; Chen, YF; Canavese, F; Li,LY*. Management and effects of residual limbus inversion followingclosed reduction in developmental hip dysplasia: Protocol for a multicenterrandomized controlled trial. FRONTIERS IN PEDIATRICS; 2023; (corresponding, 2022IF=3.569, 中科院III区)

2.       Liu, B; Hu, XY; Li, LY*; Gao, SX. TheAssociation of Asymmetric Skinfolds and the Diagnosis of DevelopmentalDysplasia of the Hip in Infants. ADVANCES IN NEONATALCARE.2022; (corresponding, 2022 IF=1.874, 中科院III区)

3.       Duan L, Canavese F, Li L*. Flexibleintramedullary nails or Spica casting? A meta-analysis on the treatment offemur fractures in preschool children aged 2-5 years. J Pediatr Orthop B. 2022; (corresponding, 2022 IF=1.473, 中科院Ⅳ区)

4.       Ma S, Zhou W, Li L*, Wang E, Zhang L, Li Q. Retrospectivecomparison of outcomes between closed and open reduction for developmentaldysplasia of the hip in children aged 6–24 months. Indian J Orthop. 2022; (corresponding, 2022 IF=1.033, 中科院Ⅳ区)

5.       Xu X, Bi X, Wang J, Gui R, Li T, Li L*,Wang B*. Identification of KANSL1 as a novel pathogenic gene for developmentaldysplasia of the hip. J Mol Med (Berl). 2022; (co-corresponding,2022 IF= 5.606, 中科院Ⅱ区)

6.       Liu B, Hu X, Li L*, Gao S. MorphologicalDevelopment of the Hip in Normal Infants Under Six Months of Age by the GrafUltrasound Method. Front Pediatr. 2022; (corresponding,2022 IF= 3.569, 中科院Ⅱ区)

7.       Zhou W, Luo W, Liu D, Canavese F, Li L*,Zhao Q. Fluoride increases the susceptibility of developmental dysplasia of thehip via increasing capsular laxity triggered by cell apoptosis and oxidativestress in vivo and in vitro. Ecotoxicol Environ Saf. 2022;(corresponding, 2022 IF= 7.129, 中科院Ⅰ区)

8.       Yuan X, Zhao Y, Li J, Chen X, Lu Z, Li L*,Guo J. Citrate-based mussel-inspired magnesium whitlockite composite adhesivesaugmented bone-to-tendon healing. J Mater Chem B. 2021;9(39):8202-8210. doi: 10.1039/d1tb01710a. (corresponding, 2022 IF=7.571, 中科院II区)

9.       Yingling Yao, Haolin Zhou, Lianyong Li#, GuoxinNan#. Epidemiological statistics of congenital thumbduplication in the Chinese population. J Orthop Surg Res. 2021; 16(1):481.(co-corresponding,2022 IF=2.677, 中科院IV 区). doi:10.1186/s13018-021-02567-3.

10.    Huajun Deng, Haibo Mei, Enbo Wang, Qiwei Li, LijunZhang, Federico Canavese, Lianyong Li*. The associationbetween fibular status and frontal plane tibial alignment post-union incongenital pseudarthrosis of the tibia. J child Orthop.2021; 15(3):261-269.(corresponding, 2022 IF=1.917, 中科院IV区)

11.    Jiahui Liu, Weizheng Zhou, Yufan Chen, LianyongLi*. Acetabular development and fate of inverted limbus in rabbits:experimental observation from an animal model. J Orthop Res. 2021; 39(12):2595-2603. (corresponding,2022 IF=3.102,中科院III区)

12.    Xiaowen Xu, Binbin Wang, Yufan Chen, Weizheng Zhou,LianyongLi*. Replicative Verification of Susceptibility Genes PreviouslyIdentified from Families with Segregating Developmental Dysplasia of the Hip. Italian Journal of Pediatrics. 2021; 47(1):140. (corresponding,2022 IF=3.288, 中科院III区)

13.    Wei Lu, Lianyong Li*, Lijun Zhang, Qiwei Li,Enbo Wang. Development of acetabular anteversion inchildren with normal hips and those with developmental dysplasia of the hip: Across-sectional study using magnetic resonance imaging. Acta Orthopaedica. 2021; 92(3):341-346. (corresponding,2022 IF=3.925, 中科院II区)

14.    Jiahui Liu, Weizheng Zhou, Lianyong Li*, LijunZhang, Qiwei Li, Enbo Wang. The fate of inverted limbus in children withdevelopmental dysplasia of the hip: clinical observation. J Orthop Res. 2021;39(7):1433-1440. (corresponding,2022 IF=3.102, 中科院III区)

15.    Sicong Liang, Weizheng Zhou, Qun Zhao, LianyongLi*. Prevalence and risk factors of burnout among Chinese pediatricorthopedic surgeons. J Pediatr Orthop. 2021; 41(1):e80-e84. doi:10.1097/BPO.0000000000001661. (corresponding，2022 IF=2.537, 中科院III区)

16.    岳宇航, 李连永*, 李祁伟, 王恩波, 刘天婧. 股骨干骨折后过度生长动物模型制作及差异蛋白质组学研究. 中华小儿外科杂志, 2021; 42(6):556-562. (corresponding)

17.    刘佳晖, 周维政, 李连永*, 张立军, 李祁伟, 王恩波. 发育性髋关节发育不良闭合复位后内翻盂唇的转归及其影响. 中华小儿外科杂志, 2021; 42(4):350-356. (corresponding)

18.    马姝宇, 李连永*, 张立军, 李祁伟, 王恩波. 闭合与单纯切开复位治疗6-24个月发育性髋关节发育不良的近期结果比较. 中国骨与关节杂志, 2021;10(3):167-174. (corresponding)

19.    岳宇航, 李连永*. 儿童下肢长骨干骨折后过度生长的影响因素及机制研究进展. 临床小儿外科杂志, 2021;20(2):181-186.(corresponding)

20.    Tianjing Liu, Enbo Wang, Qiwei Li, LianyongLi*. High prevalence of vitamin D insufficiency in Chinese childrenwith upper limb fractures. Genes Dis. 2020;7(3):408-413. doi:10.1016/j.gendis.2019.05.005. (corresponding, 2022 IF=7.243, 中科院Ⅰ区)

21.    Gui RH, Canavese F, Liu S, Li LY*, Zhang LJ, Li QW. Thepotential role of the Alsberg angle as a predictor of lateral growth disturbanceof the capital femoral epiphysis in children with developmental dysplasia ofthe hip treated by closed reduction. J child Orthop. 2020;14(2):106-111. doi:10.1302/1863-2548.14.190158. (corresponding, 2022 IF=1.917, 中科院IV区)

22.    Weizheng Zhou, Wudbhav N Sankar, Fangfang Zhang, LianyongLi*, Lijun Zhang, Qun Zhao. Evolution of concentricity after closedreduction in developmental dysplasia of the hip. Bone Joint J. 2020;102-B(5):618-626.doi: 10.1302/0301-620X.102B5.BJJ-2019-1496.R1. (corresponding, 2022 IF=5.385, 中科院II区)

23.    卢伟, 李连永*. 儿童髋臼前倾的发育规律. 临床小儿外科杂志, 2020;19(2):144-149.(corresponding)

24.    Zhang LX, Xu XW, Chen YF, Li LY*, Zhang LJ, Li QW. Mappingof developmental dysplasia of the hip to two novel regions at8q23-q24 and 12p12. Exp Ther Med. 2020;19:2799-2803. doi:10.3892/etm.2020.8513. (corresponding, 2022 IF=2.751, 中科院IV区)

25.    Weizheng Zhou, Jinghang Yu, Shiqi Wang, LijunZhang, Lianyong Li*. Use of MRI assisting the diagnosis of pediatricmedial condyle fractures of the distal humerus. J Pediatr Orthop B.  2020;29(5):445-451. doi:10.1097/BPB.0000000000000701. (corresponding, 2022 IF=1.473, 中科院IV区)

26.    余京杭, 李连永, 张立军, 李祁伟, 王恩波. 股骨近端截骨在发育性髋关节发育不良手术治疗中的必要性研究. 临床小儿外科杂志, 2019;18(11):927-934. (corresponding)

27.    刘佳晖, 李连永. 髋臼盂唇与发育性髋关节发育不良. 国际儿科学杂志, 2019;46(11):823-826.(corresponding)

28.    Chen Y, Li L, Wang E, Zhang L, Zhao Q.Abnormal expression of Pappa2 gene may indirectly affect mouse hip developmentthrough the IGF signaling pathway. Endocrine. 2019; 65(2):440-450. (corresponding,2022 IF=3.925, 中科院III区)

29.    Chen Y, Lv H, LiL, Wang E, Zhang L, Zhao Q. Expression of PAPP-A2 and IGF pathwayrelated proteins in the hip joint of normal rat and those with developmentaldysplasia of the hip. Int J Endocrinol. 2019; 2019:7651531. (corresponding, 2022IF=2.803, 中科院III区)

30.    Zhou W, Canavese F, Zhang L, Li L. Functionaloutcome of the elbow in infants with transphyseal fracture of the distalhumerus treated surgically. J Child Orthop. 2019; 13(1):47-56. (corresponding,2022 IF=1.917, 中科院IV区)

31.    岳宇航, 余京杭, 李连永, 张立军, 李祁伟, 王恩波. 股骨短缩截骨对发育性髋关节发育不良患儿下肢骨性长度的影响. 骨科临床与研究杂志, 2019; 4(03):133-137. (corresponding)

32.    王施琪, 余京杭, 李连永, 张立军, 李祁伟, 王恩波. 儿童肱骨内髁骨折的诊治特点分析. 中华小儿外科杂志, 2018; 39(11):811-815. (corresponding)

33.    张芳芳, 刘双, 李连永, 张立军. 发育性髋关节发育不良闭合复位后“同心复位”演变的系列磁共振研究. 临床小儿外科杂志, 2018;17(10):736-741.(corresponding)

职称晋升经历：

2006.06中国医科大学 附属盛京医院讲师主治医师

2010.06中国医科大学 附属盛京医院副教授副主任医师（破格晋升）

2014.12中国医科大学 附属盛京医院教授主任医师（破格晋升）

2015.03中国医科大学 遴选博士研究生导师

留学经历：

2013.02-2014.01 美国 费城儿童医院小儿骨科临床访问学者

1. 2020，中华医学科学技术奖三等奖，“发育性髋脱位治疗关键技术创新及早期预防筛查体系的建立和应用”，第一完成人

2. 2017，辽宁省自然科学学术成果奖三等奖，“CX3CR1 polymorphismsassociated with an increased risk of developmental dysplasia of the hip inhuman”，编号：173203401032909. 2017.09.19