主持课题

1. 辽宁省高等学校基本科研项目（青年项目，自然科学类）

项目名称：长链非编码RNA-SENCR对脉络膜新生血管形成作用机制的研究

项目编号：LQNK201717

资助时间：2018.01-2020.12

资助经费：5万元

2. 第65批中国博士后科学基金面上项目 (一等资助) 项目名称：SENCR结合miR-20a-ANGPT2-TIE2调控脉络膜血管形成机制

项目编号：2019M650057 资助时间：2019.06-2021.06 资助经费：12万元

3. 辽宁省教育厅 2021 年度科学研究经费项目（面上项目）

项目名称：卷积神经网络分析在视网膜新生血管检测中的应用

项目编号：LJKZ0773

资助时间：2021.09-2024.09 资助经费：5万元

主持课题

1. 辽宁省高等学校基本科研项目（青年项目，自然科学类）

项目名称：长链非编码RNA-SENCR对脉络膜新生血管形成作用机制的研究

项目编号：LQNK201717

资助时间：2018.01-2020.12

资助经费：5万元

2. 第65批中国博士后科学基金面上项目(一等资助)项目名称：SENCR结合miR-20a-ANGPT2-TIE2调控脉络膜血管形成机制

项目编号：2019M650057资助时间：2019.06-2021.06资助经费：12万元

3. 辽宁省教育厅 2021 年度科学研究经费项目（面上项目）

项目名称：卷积神经网络分析在视网膜新生血管检测中的应用

项目编号：LJKZ0773

资助时间：2021.09-2024.09资助经费：5万元

已发表代表性SCI研究成果 通讯/第一作者（含并列第一）17篇

1.Yuan W, Li J, GaoS, Sun W, Zhao F. Novel therapeutic targets for primaryopen-angle glaucoma identified through multicenter proteome-wide mendelianrandomization. Front Pharmacol. 2024 Aug 16;15:1428472. doi: 10.3389/fphar.2024.1428472.PMID: 39221148. (Impact Factor: 4.4，2区，通讯作者)

2.Yuan W, Xu X, Zhao F. Trends and hot spots in research related toaqueous humor from 2014 to 2023: A bibliometric analysis. Heliyon. 2024 Jul2;10(13):e33990. doi: 10.1016/j.heliyon.2024.e33990. PMID: 39071583. (Impact Factor: 3.4，3区，通讯作者)

3.Liu X, Zhao F, Yuan W and Xu J. Causal relationshipsbetween height, screen time, physical activity, sleep and myopia: univariableand multivariable Mendelian randomization. Front. Public Health 12:1383449.doi:10.3389/fpubh.2024.1383449. PMID: 38966704. (Impact Factor: 3，3区，并列第一)

4.Zhang X, Yuan W,Xu J, Zhao F. Application of mendelian randomization inocular diseases: a review. Hum Genomics. 2024 Jun 17;18(1):66. doi: 10.1186/s40246-024-00637-1.PMID: 38886833. (Impact Factor: 3.8，3区，通讯作者)

5.Yuan W, Xu W, XuX, Qu B, Zhao F. Exploration of potential novel drug targetsfor diabetic retinopathy by plasma proteome screening. Sci Rep. 2024 May22;14(1):11726. doi: 10.1038/s41598-024-62069-0. PMID: 38778174. (Impact Factor: 3.8，2区，通讯作者)

6. Yuan W, Li X, Wang G, Qu B, Zhao F. Association of autoimmune and allergicdiseases with senile cataract: a bidirectional two-sample Mendelianrandomization study. Front Immunol. 2024 Mar 22;15:1325868. doi:10.3389/fimmu.2024.1325868. PMID: 38585265. (Impact Factor: 5.7，2区，通讯作者)

7.Yan C, Zhao F, Gao S, Liu X, Yu T, Mu Y, Zhang L, Xu J.Observation of the effect of posterior scleral reinforcement combined withorthokeratology and 0.01% atropine in the treatment of congenital myopia: acase report. BMC Ophthalmol. 2023 Nov 28;23(1):486. doi:10.1186/s12886-023-03211-w. PMID: 38012561. (Impact Factor: 2，3区，并列第一)

8.Yuan WC, Zhao F, Xu J. Development of corneal contact lensmaterials and current clinical application of contact lenses: a review. Biointerphases. 2023 Sep 1;18(5):050801. doi: 10.1116/6.0002618.PMID: 37756594.(Impact Factor: 2.1，4区，并列第一)

9.Xu J, Zhao F, Fang J, Shi M, Pan J, Sun W, Du C. Mappingresearch trends of chronic ocular graft-versus-host disease from 2009 to 2020:a bibliometric analysis. Int Ophthalmol.2022 Jul 7. doi: 10.1007/s10792-022-02380-9. Epub ahead of print. PMID:35799074. (Impact Factor:2.029，4区，并列第一)

10.Song Y, Zhao F. Bibliometric analysis of metabolic surgeryfor type 2 diabetes: current status and future prospects. Updates Surg. 2022 Jan 30. doi: 10.1007/s13304-021-01201-5.PMID: 35094308 (Impact Factor: 2.797，3区，通讯作者)

11. Wang YC, Zhao FK, Liu Q, Yu ZY,Wang J, Zhang JS. Bibliometric analysis and mapping knowledge domain ofpterygium: 2000-2019. Int J Ophthalmol.2021 Jun 18;14(6):903-914. doi: 10.18240/ijo.2021.06.17. PMID: 34150547 (Impact Factor:1.779，3区，并列第一)

12. Zhao F, Du F, Shi D, Zhou W, Jiang Y, Ma L. 2019.Mapping research trends of retinal vein occlusion from 2009 to 2018: abibliometric analysis. PeerJ. 2019 Aug 29; 7:e7603.doi: 10.7717/peerj.7603. eCollection 2019. PMID: 31528507 (Impact Factor: 2.38，3区，第一作者)

13. Zhao F, Yu J, Yan Q, Zhang J, Shi M. Clinical Applicationof 25MHz Ultrasound Biomicroscopy for Lens Opacity Degree Measurements inPhacoemulsification. Transl Vis SciTechnol. 2019 Aug 7;8(4):18. doi: 10.1167/tvst.8.4.18.eCollection 2019 Jul. PMID:31402998 (Impact Factor: 2.112，3区，第一作者).

14. Zhao F, Du F, Zhang J, XuJ. Trends in research related to keratoconus from 2009 to 2018: abibliometric and knowledge mapping analysis. Cornea. 2019 Jul; 38(7): 847-854. doi: 10.1097/ICO.0000000000001984. PMID: 31033693 (Impact Factor: 2.215，3区，第一作者)

15. Zhao F, Anderson C, Karnes S,Zhou Q, Ma J, Jin ZG, Bhattacharjee PS, Wang S. Expression, regulation andfunction of miR-126 in the mouse choroid vasculature. Exp Eye Res. 2018 May;170:169-176. doi: 10.1016/j.exer.2018.02.026. PMID: 29501382 (Impact Factor: 2.998，2区，第一作者)

16. Zhao F, Shi B, Liu R, Zhou W, Shi D, Zhang J. Theme trends and knowledge structure on choroidal neovascularization: aquantitative and co-word analysis. BMCOphthalmol. 2018 Apr 3; 18(1):86. doi: 10.1186/s12886-018-0752-z. PMID: 29614994 (Impact Factor: 1.431，4区，第一作者)

17. Zhao F, Li L, Zhou W, Shi D, Fan Y, Ma L. Correlative factors' analysis of postural-related ocular cyclotorsionwith image-guided system. Jpn JOphthalmol. 2018 Mar; 62(2):237-242. doi: 10.1007/s10384-017-0544-7. PMID: 29134322 (ImpactFactor: 1.653，3区，第一作者)

已发表其他SCI研究成果21篇（第二作者7篇，第三作者6篇，第四作者7篇，第五作者1篇）

1. Wang X#,Wu Y#, Zhao F, Sun W, Pang C, Sun X, Zang S. Subjective dryeye symptoms and associated factors among the national general population inChina during the COVID-19 pandemic: A network analysis. J Glob Health.2023 Dec 1;13:06052. doi: 10.7189/jogh.13.06052. PMID: 38038375; PMCID:PMC10691301. (Impact Factor: 7.2)

2. Feng L, ZhaoF, Ke X, Zhao J, Shi M. Correlation Between Degree of Lens Opacity and thePhacoemulsification Energy Parameters Using Different Imaging Methods inAge-Related Cataract. Transl Vis Sci Technol. 2022 Mar2;11(3):24. doi: 10.1167/tvst.11.3.24. PMID: 35315873 (Impact Factor: 3.283)

3. SongY, Zhao F,Ma W, Li G. Hotspots and trends in liver kinase B1 research: A bibliometricanalysis. PLoS One. 2021 Nov 4;16(11):e0259240. doi:10.1371/journal.pone.0259240. PMID: 34735498 (Impact Factor: 3.240)

4. Ma W, Zhao F, Yu X, Guan S, Suo H, Tao Z, Qiu Y, Wu Y, Cao Y, Jin F. Immune-relatedlncRNAs as predictors of survival in breast cancer: a prognostic signature.J Transl Med. 2020 Nov 23;18(1):442. doi: 10.1186/s12967-020-02522-6. PMID: 33225954 (Impact Factor: 5.531)

5. Zhou W, Zhao F, Shi D, Qadri M, Jiang L, Ma L. Argon Laser Peripheral Iridoplasty and Argon Laser Pupilloplasty:Alternative Management for Medically Unresponsive Acute Primary Angle Closure. Journalof Ophthalmology. 2019 Aug 14; 2019:1876912. doi:10.1155/2019/1876912. eCollection 2019. PMID: 31511787 (ImpactFactor: 1.447)

6. Li X, Zhao F, Xin M, Li G, Luna C, Li G, ZhouQ, He Y, Yu B, Olson E, Gonzalez P, Wang S. Regulation of intraocular pressure bymicroRNA cluster miR-143/145.Sci Rep. 2017 Apr 19; 7(1):915. doi: 10.1038/s41598-017-01003-z. PMID: 28424493(Impact Factor: 4.122)

7. Hanus J, Zhao F, Wang S. Current therapeutic development for atrophicage-related macular degeneration. Br J Ophthalmol. 2015Nov 9. pii: bjophthalmol-2015-306972. doi: 10.1136/bjophthalmol-2015-306972. Review. PMID: 26553922 (Impact Factor: 3.036)

8. JiangB, Hong N, Zhao F, Dong F. Visualization and analysis of mappingknowledge domains for optic neuritis: a bibliometric research from 2013 to2022. Int Ophthalmol. 2024 Feb 12;44(1):57. doi:10.1007/s10792-024-02948-7. PMID: 38342798 (Impact Factor: 1.6)

9. Yu ZY, Wu L, Zhao FK, PengC, Wang CX, Qu B. RNA-seq reveals transcriptome changes of the embryoniclens cells in Prox1 tissue specific knockout mice. Eur Rev Med Pharmacol Sci. 2019 Sep;23(18):7740-7748. doi:10.26355/eurrev_201909_18983. PMID: 31599446 (Impact Factor: 2.721)

10. Ma W, Shi B, Zhao F, Wu Y, Jin F. Systematic analysis of breastatypical hyperplasia-associated hub genes and pathways based on text mining. Eur J Cancer Prev. 2018 Nov 2. doi:10.1097/CEJ.0000000000000494. PMID: 30394935 (Impact Factor: 2.886)

11.Li J, Qin Y, Zhao FK, Wu D, He XF, Liu J, Zhao JY, Zhang JS. Anterior segment dysgenesiscorrelation with epithelial-mesenchymal transition in Smad4 knockout mice.Int J Ophthalmol. 2016 Jul 18; 9(7):943-7. doi:10.18240/ijo.2016.07.02.PMID:27500098 (Impact Factor: 0.705)

12. BhattacharyaD, Ning Y, Zhao F, Stevenson W, ChenR, Zhang J, Wang M. Tear Production After Bilateral Main Lacrimal GlandResection in Rabbits. Invest OphthalmolVis Sci. 2015 Dec 1; 56(13):7774-83.doi: 10.1167/iovs.15-17550. PMID:26641554 (ImpactFactor: 3.427)

13. Zhu L, Lee B, ZhaoF, Zhou X, Chin V, Ling SC, Chen Y. Modulation of Airway EpithelialAntiviral Immunity by Fungal Exposure. Am J Respir Cell Mol Biol. 2014 Jun; 50(6):1136-43. doi: 10.1165/rcmb.2013-0357OC. PMID:24428709 (Impact Factor:3.985)

14. Yan C, Zhao J, QinY, Zhao F, Ji L, Zhang J. Overexpression of ATG4a promotesautophagy and proliferation, and inhibits apoptosis in lens epithelial cellsvia the AMPK and Akt pathways. Mol Med Rep. 2020 Aug;22(2):1295-1302. doi:10.3892/mmr.2020.11205. Epub 2020 Jun 2. PMID: 32626969 (Impact Factor: 2.1)

15. Shi B, Wei W, Qin X, Zhao F, Duan Y, Sun W, Li D, Cao Y. Mapping theme trends and knowledge structure onadipose-derived stem cells: a bibliometric analysis from 2003 to 2017. Regen Med. 2019 Jan; 14(1): 33-48. doi:10.2217/rme-2018-0117. PMID: 30547725 (Impact Factor: 2.992)

16. Zhou Q, Frost RJA,Anderson C, Zhao F, Ma J, Yu B, WangS. Let-7contributes to diabetic retinopathy but represses pathological ocularangiogenesis. Mol Cell Biol. 2017 Jun 5. pii:MCB.00001-17. doi:10.1128/MCB.00001-17. PMID: 28584193 (Impact Factor: 4.398)

17. Zhou Q, Anderson C,Hanus J, Zhao F, Ma J, Yoshimura A,Wang S. Strand and cell-type specific function of microRNA-126 in angiogenesis.MolTher. 2016 Oct; 24(10):1823-1835.doi: 10.1038/mt.2016.108. PMID: 27203443 (Impact Factor: 6.938)

18. Li J, Wang S, Anderson C, Zhao F, Qin Y, Wu D, Wu X, Liu J,He X, Zhao J, Zhang J. Requirementof Smad4 from Ocular Surface Ectoderm for Retinal Development. PLoSOne. 2016 Aug 5;11(8):e0159639. doi: 10.1371/journal.pone.0159639. PMID: 27494603(Impact Factor: 2.766)

19. Ning Y,Bhattacharya D, Jones RE, Zhao F,Chen R, Zhang J, Wang M. Evaluating the Functionality of Conjunctiva Usinga Rabbit Dry Eye Model. J Ophthalmol. 2016; 2016:3964642. doi: 10.1155/2016/3964642. Epub 2016 Mar 20.PMID:27088007 (Impact Factor: 1.712)

20. Song Y,Chen B, Jiang L, Zhao F, Feng X. Global Trends of Treatment for NAFLDfrom 2012 to 2021: A Bibliometric and Mapping Analysis. Endocr MetabImmune Disord Drug Targets. 2023 Oct 6. doi:10.2174/0118715303230418230925060312. Epub ahead of print. PMID: 37855283. (Impact Factor: 1.9)

21. Zhang X,Nakahara Y, Xuan D, Wu D, Zhao FK,Li XY, Zhang JS. Study on the optical property and biocompatibility of a tissueengineering cornea. Int J Ophthalmol. 2012; 5(1):45-9. doi: 10.3980/j.issn.2222-3959.2012.01.09.PMID:22553753 (Impact Factor: 0.119)

已发表中文核心期刊研究成果 通讯/第一作者4篇

1. 张熙然, 袁韦辰,李祥瑞,徐菲儿,赵芳坤.孟德尔随机化在常见眼病中的研究进展[J]. 国际眼科杂志, 2024, 24 (05): 784-789.

2. 王宏娜,鲁元媛,丁香英,赵芳坤,许军.配戴夜戴型角膜塑形镜对青少年近视患者泪膜稳定性的影响[J].中国医科大学学报,2019,48(12):1118-1121.

3. 丁香英,鲁元媛,赵芳坤,王宏娜,许军.青少年低中度近视患者配戴角膜塑形镜前后黄斑部脉络膜厚度的变化[J].中国医科大学学报,2019,48(09):822-827.

4. 赵芳坤,张劲松,施蓓,宋雨凌,许军.糖尿病视网膜病变基因相关研究热点的文献计量学分析[J].中国医科大学学报,2018,47(12):1067-1071.

5. 解晓丹，赵江月，赵芳坤，秦宇，张劲松. miR-204调控SIRT1在人晶状体上皮细胞凋亡中机制研究[J].中国实用眼科杂志，2017,35(05):527-532.

6. 赵芳坤,秦宇,李晶,张劲松.长链非编码RNA在眼科疾病中的研究进展[J].国际眼科杂志, 2016,16(08):1469-1473.

7. 尚琢,彭程,赵芳坤,刘野,赵江月,张劲松.心理干预对青光眼患者生活质量的影响[J].中国医科大学学报, 2012,41(02):187-189.

8. 赵芳坤,赵江月,李嶔,于佳明,刘秋芳,赵恂,张劲松.紫外线诱导的人晶状体上皮细胞氧化损伤与小窝蛋白1 mRNA表达量下降有关[J].中国医科大学学报,2011,40(02):126-130.

1. 2019.09-2020.09 美国加州大学伯克利分校 (Universityof California, Berkeley)，博士后

视光学系 (School ofOptometry)

合作导师：Prof. ChristineWildsoet; Dr. Yue Liu

2. 2014.12-2016.03 美国杜兰大学 (TulaneUniversity)，交流访问学者(J1)

细胞生物学系 (Cellularand Molecular Biology)

合作导师：Dr.Shusheng Wang

3. 2012.02-2013.02 美国亚利桑那大学 (Universityof Arizona)，交流访问学者(J1)

药理学系，眼科学系 (Departmentof Pharmacology; Department of Ophthalmology)

合作导师：Dr. YinChen; Dr. Mingwu Wang

4. 2010.08-2010.09 日本东北大学 (TohokuUniversity)，交换学生

眼科学系 (Departmentof Ophthalmology)

合作导师：布施昇男

2020-2021年度“十佳”学生最喜爱的教师称号；2023-2024年度“十佳”学生最喜爱的教师称号