课题名称

起止时间

出资单位

资助金额(万元)

胰腺癌侵袭转移密切相关的分子回路核内下游信号分子的鉴定

2010/01-2012/12

国家自然基金委员会生命科学部

31

开腹纳米刀联合氟尿嘧啶植入剂治疗局部进展期胰腺癌的有效性、安全性多中心临床研究

2017/09-2019/09

国家卫生计生委医药卫生科技发展研究中心

50

新型胰腺癌早期诊断方法的临床应用与推广

2021/07-2022/06

中央引导地方科技发展专项项目

30

机器人胰十二指肠切除术中应用主胰管空肠桥式导管引流的围手术期疗效评价

2021/01-2023/12

辽宁省重点研发联合资助计划项目

30

外泌体TNC介导的信号通路在胰腺癌侵袭转移中的作用机制

2018/09-2021/08

辽宁省科学技术厅

5

Integrin活化MAPK信号通路调控胰腺癌侵袭转移分子机制的研究

2017/01-2018/12

辽宁省人社厅

2

整合素α6β4通过活化MMP-7/EGFR/MEK2/ERK2正反馈分子回路参与调控胰腺癌侵袭转移分子机制的研究

2017/02-2019/12

沈阳市科技局

5

MiR-222调控胰腺癌侵袭转移的分子机制研究

2014/01-2016/12

辽宁省科学技术厅

5

基质金属蛋白酶-7活化对胰腺癌细胞解离相关信号转导的调控机制研究

2010/01-2012/12

辽宁省教育厅

3

胰腺癌侵袭转移密切相关的疯子回路核内下游信号分子的坚定

2009/07-2011/12

教育部科技发展中心

5

MMP-7活化调控胰腺癌细胞解离相关信号转导的研究

2008/02-2010/12

辽宁省科学技术厅

5

留学回国人员科研启动基金

2007/09-2009/09

教育部

5

序号

论文（著作）名称

发表时间

刊物（会议、出版社）名称

1

A combination of circulating tumor cells and CA199 improves the diagnosis of pancreatic cancer.

2022

Journal of Clinical Laboratory Analysis

2

Prognostic Value and Correlation With Tumor Immune Infiltration of a Novel Metabolism-Related Gene Signature in Pancreatic Cancer.

2022

Frontiers in Oncology

3

Syntenin Regulated by miR-216b Promotes Cancer Progression in Pancreatic Cancer.

2022

Frontiers in Oncology

4

A necroptosis-related gene signature for predicting prognosis, immune landscape, and drug sensitivity in hepatocellular carcinoma.

2022

Cancer Medicine

5

Salvianolic acid B attenuates oxidative stress-induced injuries in enterocytes by activating Akt/GSK3β signaling and preserving mitochondrial function

2021

Eur J Pharmacol

6

Identification of Novel Metabolism-Associated Subtypes for Pancreatic Cancer to Establish an Eighteen-Gene Risk Prediction Model.

2021

Front Cell Dev Biol

7

STING-driven interferon signaling triggers metabolic alterations in pancreas cancer cells visualized by [¹⁸F]FLT PET imaging

2021

Proc Natl Acad Sci U S A

8

Multi-omics analysis based on integrated genomics, epigenomicand transcriptomics in pancreatic cancer

2020

Epigenomics

9

Identification of dissociation factors in pancreatic Cancer using a mass spectrometry-based proteomic approach

2020

BMC Cancer

10

A Prognostic Prediction Model Developed Based on Four CpG Sites and Weighted Correlation Network Analysis Identified DNAJB1 as a Novel Biomarker for Pancreatic Cancer

2020

Frontiers in Oncology

11

Synergismof PARP inhibitor fluzoparib (HS10160) and MET inhibitor HS10241 in breast and ovarian cancer cells

2019

American Journal of Cancer Research

12

Integrated analysis identifies a pathway-related competing endogenous RNA network in the progression of pancreatic cancer

2019

BMC Cancer

13

Identification of RE1-Silencing Transcription Factor as a Promoter of Metastasis in Pancreatic Cancer

2019

Frontiers in oncology

14

ITGA6 and RPSA synergistically promote pancreatic cancer invasion and metastasis via PI3K and MAPK signaling pathways

2019

Experimental Cell Research

15

Exosomal Tenascin-c induces proliferation and invasion of pancreatic cancer cells by WNT signaling

2019

OncoTargets and Terapy

16

TSPAN1 upregulates MMP2 to promote pancreatic cancer cell migration and invasion via PLCγ

2019

Oncology Reports

17

Synergism of PARP inhibitor fluzoparib (HS10160) and MET inhibitor HS10241 in breast and ovarian cancer cells

2019

American Journal of Cancer Research

18

Exosomal zinc transporter ZIP4 promotes cancer growth and is a novel diagnostic biomarker for pancreatic cancer

2018

Cancer Science

19

Identifcation of PGAM1 as a putative therapeutic target for pancreatic ductal adenocarcinoma metastasis using quantitative proteomics

2018

OncoTargets and Terapy

20

Differential expression profiles of microRNAs in highly and weakly invasive and metastatic pancreatic cancer cells

2018

Oncology Letters

21

MiR-221 induces autophagy through suppressing HDAC6 expression and promoted apoptosis in pancreatic cancer

2018

Oncology Letters

22

Phosphoglycerate mutase 1 (PGAM1) promotes pancreatic ductal adenocarcinoma (PDAC) metastasis by acting as a novel downstream target of PI3K/Akt/mTOR pathway

2018

Oncology Research

23

ROS mediated EGFR/MEK/ERK/HIF-1α Loop Regulates Glucose metabolism in pancreatic cancer

2018

Biochemical and Biophysical Research 

Communications

24

Integrated whole genome microarray

analysis and immunohistochemical assay

identifies COL11A1, GJB2 and CTRL as predictive biomarkers for pancreatic cancer

2018

Cancer Cell International

25

IRS-1 regulates proliferation,invasion and metastasis of pancreatic cancer cells through MAPK and PI3K signaling pathways

2018

International journal of Experimental Pathology

26

UCA1 Regulates the Growth and Metastasis of Pancreatic Cancer by Sponging miR-135a

2017

Oncology Research

27

Efficacy of laparoscopic ultrasonography in laparoscopic resection of insulinoma

2017

Endosc Ultrasound

28

The role of pancreatic cancer-derived exosomes in cancer progress and their potential application as biomarkers

2017

Clinical and Translational Oncology

29

Quantitative secretomic analysis of pancreatic cancer cells in serum-containing conditioned medium

2016

Scientific Reports

30

Phosphoproteome Analysis of Invasion and Metastasis-Related Factors in Pancreatic Cancer Cells

2016

PLoS One

31

Nanoparticle-Mediated Local Delivery of an Antisense TGF-beta 1 Construct Inhibits Intimal Hyperplasia in Autogenous Vein Grafts in Rats

2012

PLos One

32

Analysis of invasion-metastasis in pancreatic cancer: Correlation between the expression and arrangement of tight junction protein-2 and cell dissociation in pancreatic cancer cells

2010

Mol Med Rep

33

Genomic analysis of invasion-metastasis-related factors in pancreatic cancer cells

2010

Exp Ther Med

34

Involvement of the expression and redistribution of claudin-23 in pancreatic cancer cell dissociation

2010

Molecular Medicine Reports

35

MEK1 and MEK2 isoforms regulate distinct functions in pancreatic cancer cells

2010

Oncol Rep

36

Analysis of the invasion-metastasis mechanism in pancreatic cancer: Involvement of plasmin(ogen) cascade proteins in the invasion of pancreatic cancer cells.

2006

International Journal of Oncology

37

Zonula Occludens-1 (ZO-1) Redistribution Is Involved in the Regulation of Cell Dissociation in Pancreatic Cancer Cells

2005

Digestive Diseases and Sciences

38

Involvement of matrix metalloproteinase-7 in invasion of pancreatic cancer cells through activation of EGFR-mediated MEK /ERK signal transduction pathway

2005

J Clin Pathol

39

Analysis of invasion-metastasis mechanism in pancreatic cancer:Involvement of tight junction transmembrane protein occludin and MEK/ERK signal transduction pathway in cancer cell dissociation

2004

Oncology Reports

40

Arrangement of expression and distribution of tight junction protein claudin-1 in cell dissociation of pancreatic cancer cells

2004

International Journal of Oncology

41

Involvement of the mitogen-actived protein kinase kinase 2 in the induction of cell dissociation in pancreatic cancer

2004

International Journal of Oncology

42

Protective effect of exogenous adenosine triphosphate on hypothermically preserved rat liver

2004

World J Gastroenterol

43

Relationship between activation of epidermal growth factor receptor and cell dissociation in pancreatic cancer

2004

Int J Oncol

44

Relationship between the expression of extracellular signal-regulated kinase 1/2 and the dissociation of pancreatic cancer cells: Involvement of ERK1/2 in the dissociation status of cancer cells

2004

Int J Oncol

45

胰腺癌差异表达基因的筛选及其预后价值：生物信息学分析

2022

现代肿瘤医学

46

外泌体在胰腺癌中的研究现状与进展

2019

现代肿瘤医学

47

原发性甲状旁腺功能亢进症患者术后低钙血症的发病率及临床特点

2018

国际外科学杂志

48

甲状腺未分化癌的影像学特点分析

2018

现代肿瘤医学

49

Braun吻合对胰十二指肠切除术后并发症影响的Meta分析

2017

肝胆胰外科杂志

50

SSPPD和PPPD的疗效比较

2017

中国普外基础与临床杂志

51

胰腺肿瘤切除患者长期应用质子泵抑制剂诱发难治性低钠血症的临床观察

2017

临床外科杂志

52

热激蛋白10在恶性肿瘤中的研究进展

2017

医学综述

53

MicroRNA与胰腺癌关系研究进展

2016

临床军医杂志

54

NDRG1下调对吉西他滨干预人胰腺癌细胞PANC-1增殖及凋亡的影响

2016

肝胆胰外科杂志

55

PRDX1在人胰腺导管腺癌中的表达及其与病理指标的关系

2016

现代肿瘤医学

56

下调NDRG1表达对胰腺癌细胞增殖与凋亡的影响

2015

中国普通外科杂志

57

NDRG1与MMP-7在胰腺导管腺癌中的表达及意义

2015

现代肿瘤医学

58

下调NDRC1表达对胰腺癌细胞增殖、转移及侵袭的影响

2015

现代肿瘤医学

59

下调自噬性相关蛋白表达对胰腺癌PANC-1细胞增殖的影响

2015

中国综合临床

60

上调N-myc下游调节基因1表达对胰腺癌细胞增殖及凋亡的作用

2015

中国现代医学杂志