1. 国家自然科学基金面上项目：Caspr3与Notch1互作维持脑微血管生成和抑制脑微血管退化的机制，32171108，2022.1-2025.12；

2.  国家自然科学基金面上项目：Caspr与ATP1B3互作调控钠钾泵装配和维持神经血管单元功能的机制，31771258，2018.1-2021.12；

等。

1. Liu H, WeiJY, Li Y, Ban M, Sun Q, Wang HJ, Zhao D, Tong PG, Wang L, Wang KJ, Yue JL,Zhang HY, Fang WG, Liu DX, Shang DS, Li B, Jin YP, Cao L, Zhao WD, Chen YH.Endothelial depletion of Atg7 triggers astrocyte-microvascular disassociationat blood-brain barrier. J Cell Biol. 2023 May 1;222(5):e202103098. 

2. Li Y, Wei JY, Liu H,Wang KJ, Jin SN, Su ZK, Wang HJ, Shi JX, Li B, Shang DS, Fang WG, Qin XX, ZhaoWD, Chen YH. An oxygen-adaptive interaction between SNHG12 and occludinmaintains blood-brain barrier integrity. Cell Rep. 2022 Apr 12;39(2):110656. 

3. Zhang SH, Liu DX, Wang L,Li YH, Wang YH, Zhang H, Su ZK, Fang WG, Qin XX, Shang DS, Li B, Han XN, ZhaoWD, Chen YH. ACASPR1-ATP1B3 protein interaction modulates plasma membrane localization ofNa+/K+-ATPase in brain microvascular endothelial cells. J Biol Chem. 2019 Apr 19;294(16):6375-6386.

4. Zhao WD, Liu DX, Wei JY,Miao ZW, Zhang K, Su ZK, Zhang XW, Li Q, Fang WG, Qin XX, Shang DS, Li B, LiQC, Cao L, Kim KS, Chen YH.Caspr1 is a host receptor for meningitis-causingEscherichia coli. Nat Commun. 2018 Jun12;9(1):2296. 

5. Shang S, Yang YM, Zhang H, Tian L, Jiang JS, Dong YB, Zhang K, Li B, Zhao WD, Fang WG, Chen YH. IntracerebralGM-CSF contributes totransendothelial monocytemigration in APP/PS1 Alzheimer's disease mice. J Cereb Blood Flow Metab. 2016Nov;36(11):1978-1991.

6. Tian L,Zhang K,Tian ZY,Wang T,Shang DS,Li B,Liu DX,Fang WG,Wang ZY,Chen YH.Decreased expression of cathepsin D in monocytes is related to the defectivedegradation of amyloid-β in Alzheimer's disease. J Alzheimers Dis. 2014;42(2):511-20.

7. LiB, Wang C, Zhang Y, Zhao XY, Huang B, Wu PF, Li Q, Li H, Liu YS, Cao LY, Dai WM, Fang WG, ShangDS, Cao L, ZhaoWD, Chen YH. Elevated PLGF contributes to small cell lung cancer brainmetastasis. Oncogene. 2013 Jun13;32(24):2952-62.

8. ZhaoWD, Liu W, Fang WG, Kim KS, Chen YH. Vascular endothelial growth factorreceptor 1 contributes to Escherichia coli K1 invasion of human brainmicrovascular endothelial cells through PI3K/Akt signaling pathway. Infect Immun, 2010, 78(11): 4809-4816.

9. LiuYJ, Guo DW, Tian L, Shang DS, Zhao WD, Li B, Fang WG, Zhu L, Chen YH. PeripheralT cells derived from Alzheimer's disease patients overexpress CXCR2contributing to its transendothelial migration, which is microglialTNF-alpha-dependent. Neurobiol Aging，2010，31(2):175-88.

10. LiM, Shang DS, Zhao WD, Tian L, Li B, Fang WG, Zhu L, Man SM, Chen YH. Amyloid βinteraction with receptor for advanced glycation end products up-regulatesbrain endothelial CCR5 expression and promotes T cells crossing the blood-brainbarrier. J Immunol, 2009, 182(9):5778-5788.

人才入选项目：教育部跨世纪人才；国务院特殊津贴专家；辽宁省特聘教授。

是否具有国际合作：有。

是否具有国外访学经历：有。
所在团队及任职情况：发育细胞生物学团队；教育部医学细胞生物学和国家卫健委细胞生物学重点实验室主任。

所在平台情况：中国医科大学生命科学学院，发育细胞生物学教研室；教育部医学细胞生物学和国家卫健委细胞生物学重点实验室。