ThPOK通过调控TRIB2/AKT/mTOR信号通路维持CD4 T细胞初始性在T细胞衰老中的作用及其分子机制研究，国家自然科学基金，面上项目，32270938，2023-01-01至2026-12-31，54万元，在研，主持

衰老相关Gzmk+ CD8T细胞通过Gzmk/PAR1诱导衰老炎症在衰老中的作用与机制研究，国家自然科学基金，面上项目，82571797，2026-01-01至2029-12-31，49万元，在研，主持

T细胞衰老的作用与机制，教育部，教育部博士后海外引才专项，2024-01-01至2026-12-31，60万元，在研，主持

免疫衰老的机制和药物干预研究，科技部，国家重点研发计划青年科学家项目，2023YFC3606600，2024-01-01至2026-12-31，100万/300万元，在研，项目骨干

中青年科技创新人才支持计划，RC220150，沈阳科技局，2022-01至2024-12，15万元，结题，主持

ThPOK通过调控TRIB2/AKT/mTOR信号通路维持CD4 T细胞初始性在T细胞衰老中的作用及其分子机制研究，国家自然科学基金，面上项目，32270938，2023-01-01至2026-12-31，54万元，在研，主持

衰老相关Gzmk+ CD8T细胞通过Gzmk/PAR1诱导衰老炎症在衰老中的作用与机制研究，国家自然科学基金，面上项目，82571797，2026-01-01至2029-12-31，49万元，在研，主持

T细胞衰老的作用与机制，教育部，教育部博士后海外引才专项，2024-01-01至2026-12-31，60万元，在研，主持

免疫衰老的机制和药物干预研究，科技部，国家重点研发计划青年科学家项目，2023YFC3606600，2024-01-01至2026-12-31，100万/300万元，在研，项目骨干

中青年科技创新人才支持计划，RC220150，沈阳科技局，2022-01至2024-12，15万元，结题，主持

Cao W#,Sturmlechner I, Zhang H, Jin J, Hu B, Jadhav RR, Fang F, Weyand CM. Goronzy JJ. TRIB2 safeguards naïve T cell homeostasisduring aging. Cell Reports. 2023（#共同通讯作者)

GuoL, Li X, Gould T, Wang Z-Y & Cao W.T cell aging and Alzheimer's disease. Frontiers in immunology.  2023.

Cao W,Fang F, Gould TM, Li X, Kim C, Gustafson CE, Lambert S, WeyandCM, and Goronzy JJ. The ecto-ATPase CD39 is a negative checkpoint in the generation offollicular helper cells. J Clin Invest. 2020.

Cao W, Guo J, Wen X, Miao L, LinF, Xu G, Ma R, Yin S, Hui Z, Chen T, Guo S, Chen W, Huang Y, Liu Y, Wang J, Wei L, Wang L. CXXC finger protein 1 is critical for T cell intrathymic developmentthrough regulating H3K4 trimethylation. Nature Communications. 2016.

FangF, Cao W*,Zhu W, Lam N, Li L, Gaddam S, Wang Y, Kim C, Lambert S, Zhang H, Hu B, FarberD, Weyand, CM, Goronzy JJ. The cell-surface 5’-nucleotidase CD73 defines afunctional T memory cell subset that declines with age. Cell Reports. 2021. (*共同第一作者)

FangF, Cao W*, Mu Y, Okuyama H, Li L, QiuJ, Weyand CM and Goronzy JJ. IL-4 prevents adenosine-mediated immunoregulationby inhibiting CD39 expression. JCI insight. 2022. (*共同第一作者)

ZhangH, Jadhav RR, Cao W, Goronzy IN,Zhao TV, Jin J, Ohtsuki S, Hu Z, Morales J, Greenleaf WJ, Weyand CM, Goronzy JJ.Aging-associated HELIOS deficiency in naive CD4+ T cells alters chromatinremodeling and promotes effector cell responses. Nature Immunology. 2022

Jin J, Kim C, Xia Q, Gould TM, Cao W, Zhang H, Li X, Weiskopf D, Grifoni A, Sette A, Weyand, CM, Goronzy JJ. Activation of mTORC1 at late endosomes misdirects Tcell fate decision in older individuals. Science Immunology. 2021.

LambertS, Cao W, Zhang H, ColvilleA, Liu J, Weyand CM, Goronzy JJ, Gustafson CE. The influence ofthree-dimensional structure on naïve T cell homeostasis and aging. Frontiersin Aging. 2022

JinJ, Li X, Hu B, Kim, Cao W,Zhang H, Weyand CM, and Goronzy JJ. FOXO1 deficiency impairsproteostasis in aged T cells. Science Advances. 2020.

GustafsonCE, Jadhav RR, Cao W, Qi Q,Pegram M, Tian L, Weyand CM, and Goronzy JJ. Immunecell repertoires in breast cancer patients after adjuvant chemotherapy. JCI Insight,2020

Li Y, Shen Y, Jin K, Wen Z, Cao W, Wu B, Wen R, Tian L, Berry GJ, Goronzy JJ andWeyand CM. The DNA repair nuclease MRE11A functions as a mitochondrialprotector and prevents T cell pyroptosis and tissue inflammation. Cell metabolism. 2019.

Lin F, Meng X, Guo Y, Cao W, Liu W, Xia Q, Hui Z, Chen J, Hong S,Zhang X, Wu C, Wang D, Wang J, Lu L, Qian L, Wei L, Wang L. Epigenetic initiation of the TH17 differentiationprogram is promoted by Cxxc finger protein 1. Science advances. 2019.

Liu X, Yin S, Cao W, Fan W, Yu L, Yin L, WangL, Wang J. Runt-related transcription factor 3 is involved in the change ofphenotype and function in ThPok-deficient invariant natural killer T-cells. CellMol Immunol. 2012.

Li M, CaoW*, Liu H, Zhang W, Liu X, Cai Z, Guo J, Wang X, Hui Z, Zhang H, WangJ, Wang L. MCPIP1 Down-regulates IL-2 Expression through an ARE-independentPathway. PLoS One. 2012.  (*共同第一作者)

是否具有国际合作：是
是否具有国外访学经历：斯坦福大学博士后、梅奥医学中心助理研究员
所在团队及任职情况：辽宁省神经系统重大慢病重点实验室，PI