国家自然科学基金面上项目，82271931，MZF1-SMG1-p62-Keap1调控Nrf2在慢性乙醇暴露诱导认知功能障碍中的作用机制及富马酸二甲酯的保护作用，2023.01-20246.12，52万元

1.    Yao Hui#, ZhangDalin#, Yu Hao, Yuan Huiya, Shen Hui, Lan Xinze, Liu Hao, ChenXiaohuan, Meng Fanyue, Wu Xu, Zhang Guohua*, Wang Xiaolong*.Gut microbiota regulates chronic ethanol exposure induced depressive likebehavior through hippocampal NLRP3 mediated neuroinflammation. MolecularPsychiatry. 2023, 28:919-930. (1区，2022IF=11.0)

2.    Yao Hui, Zhang Dalin, Yu Hao,Shen Hui, Lan Xinze, Liu Hao, Meng Fanyue, Wu Xu, Zhang Guohua*, Wang Xiaolong*.The microbiota-gut-brain axis in pathogenesis of depression: a narrativereview. Physiology & Behavior. 2023, 260: 114056. (3区，2022IF=2.9)

3.    Yao Hui#, ZhangDalin#, Yu Hao, Shen Hui, Lan Xinze, Liu Hao, Chen Xiaohuan, Wu Xu*,Zhang Guohua*, Wang Xiaolong*. Chronic ethanol exposureinduced anxiety-like behavior by altering gut microbiota and GABA system.Addiction Biology. 2022, 27(5):e13203. (2区，IF=3.4)

4.    Yao Hui#, ZhangDalin#, Yu Hao, Shen Hui, Lan Xinze, Liu Hao, Chen Xiaohuan, Wu Xu,Zhang Guohua*, Wang Xiaolong*. AMPAkine CX516 alleviated chronic ethanolexposure-induced neurodegeneration and depressive-like behavior in mice.Toxicology and Applied Pharmacology. 2022, 439:115924. (2区，IF=3.8)

5.    Yao Hui#, Shen Hui#,Yu Hao#, Wang Changliang, Ding Runtao, Lan Xinze, Dilichati Tash, WuXu*, Wang Xiaolong*, Zhang Guohua*. Chronic Ethanol Exposure InducedDepressive-like Behavior in Male C57BL/6 N Mice by Down-regulating GluA1. Physiology & Behavior. 2021, 234:113387. (3区，IF=3.742)

6.    Xia Zhixiu#, WangChangliang, Wang Xiaolong, Yu Hao, Yao Hui, Shen Hui, Lan Xinze, Wu Xu, ZhangGuohua*. NCX3 alleviates ethanol-induced apoptosis of SK-N-SH cells via theelimination of intracellular calcium ions. Toxicology in Vitro. 2021, 72:105104.(3区，IF=3.685)

7.    Feng Chunmei#, ZhangChaoxu#, Wang Pengfei, Wang Xiaolong, You Jiabin, Zhang Guohua*, andYu Hao*. Expression of FcεRIα and tryptase in human lung tissue duringdrug-induced anaphylactic death. Forensic Science, Medicine and Pathology. 2021,17:547-552. (3区，IF= 2.456)

8.    Wang Xiaolong#, YuHao#, Wang Changliang, Liu Yang, You Jiabin, Wang Pengfei, XuGuohui, Shen Hui, Yao Hui, Lan Xinze, Zhao Rui, Wu Xu*, Zhang Guohua*. ChronicEthanol Exposure Induces Neuroinflammation in H4 cells through TLR3 / NF-κBPathway and Anxiety-like Behavior in Male C57BL/6 Mice. Toxicology. 2020, 446:152625.(2区，IF=4.221)

9.    Xu Guohui#, WangXiaolong#, Yu Hao, Wang Changliang, Liu Yang, Zhao Rui*, ZhangGuohua*. Beclin 1, LC3, and p62 expression in Paraquat-induced PulmonaryFibrosis. Human & Experimental Toxicology. 2019, 38(7):794-802. (4区，IF=2.067)

10. Wang Changliang#,Wang Xiaolong#, Li Yan#, Xia Zhixiu, Liu Yang, Yu Hao, XuGuohui, Wu Xu, Zhao Rui, Zhang Guohua*. Chronic Ethanol Exposure Reduces theExpression of NCX3 in the Hippocampus of Male C57BL/6 Mice. Neuroreport. 2019,30(6):397-403. (4区，IF=1.394)

11. Feng Chunmei#, WangXin#, Yu Hao, Wang Xiaolong, Zhang Guohua*. Genetic polymorphisms,forensic efficiency, and phylogenetic analysis of 15 mautosomal STR loci in theUygur population of Ili Kazakh Autonomous Prefecture, Northwestern China.Annals of Human Genetics. 2019, 83(1): 46-53. (4区，IF=1.368)

12. Wang Xiaolong#, YuHao#, You Jiabin, Wang Changliang, Feng Chunmei, Liu Zhaodi, Li Ya,Wei Rucheng, Xu Siqi, Zhao Rui, Wu Xu*, and Zhang Guohua*. Memantine CanImprove Chronic Ethanol Exposure-induced Spatial Memory Impairment in MaleC57BL/6 Mice by Reducing Hippocampal Apoptosis. Toxicology. 2018, 406-407:21-32.(2区，IF=3.547)

13. Wang Hongbo#, WangXiaolong#, Li Yan#, Yu Hao, Wang Changliang, FengChunmei, Xu Guohui, Chen Jiajun, You Jiabin, Wang Pengfei, Wu Xu, Zhao Rui*,and Zhang Guohua*. Chronic ethanol exposure induces SK-N-SH cell apoptosis byincreasing N-methyl-d-asparticacid receptor expression and intracellular calcium. Experimental andTherapeutic Medicine. 2018, 15(4):3791-3800. (4区，IF=1.448)

14. Feng Chunmei#, WangXin#, Wang Xiaolong, Yu Hao, and Zhang Guohua*. Geneticpolymorphisms, forensic efficiency and phylogenetic analysis of 15 autosomalSTR loci in the Kazak population of Ili Kazak Autonomous Prefecture,Northwestern China. Annals of Human Biology. 2018, 45(2):160-165. (4区，IF=1.588)

15. Wang Xiaolong#, ChenJiajun#, Wang Hongbo, Yu Hao, Wang Changliang, You Jiabin, WangPengfei, Feng Chunmei, Xu Guohui, Wu Xu, Zhao Rui, Zhang Guohua*. Memantine CanReduce Ethanol-Induced Caspase-3 Activity and Apoptosis in H4 Cells byDecreasing Intracellular Calcium. Journal of Molecular Neuroscience. 2017,62(3-4):402-411. (3区，IF=2.454)

16. Yu Hao#, WangChangliang#, Wang Xiaolong, Wang Hongbo, Zhang Chunan, You Jiabin,Wang Pengfei, Feng Chunmei, Xu Guohui, Zhao Rui, Wu Xu*, Zhang Guohua*.Long-term ethanol exposure downregulates tight junction proteins through theprotein kinase Cα signaling pathway in human brain microvascular endothelialcells. Experimental and Therapeutic Medicine. 2017, 14(5):4789-4796. (4区，IF=1.41)

17.    张楚楠, 于浩, 王晓龙, 王鹏飞, 冯春梅, 尤家斌, 王昌亮, 徐国辉, 张国华*. 过敏性休克死亡豚鼠肺组织中CD63的表达. 法医学杂志. 2019, 35(4): 396-401.

18.    朱泽磊, 王鹏, 尤家斌, 岳强, 王鹏飞, 王晓龙, 张楚楠, 张国华*. IMA和H-FABP在心源性猝死法医学诊断中的应用. 法医学杂志. 2017, 33(4):393-396.

19.    王鹏, 朱泽磊, 朱宁, 于浩, 岳强, 王晓龙, 冯春梅, 王昌亮, 张国华*. 缺血修饰白蛋白在急性缺血性心脏病中的法医学应用. 法医学杂志. 2017,33(5):493-496.

20.    樊雅青,徐国辉,于浩,张楚楠,张国华*.慢性酒精中毒引起的脑神经损害与Aβ蛋白变化的相关性[J].解剖科学进展,2017,23(02):189-192.

辽宁省“百千万人才工程”千层次人才

沈阳市高层次人才——拔尖人才

是否具有国际合作：

是否具有国外访学经历：

2006年6月-2007年12月，在美国哈佛大学医学院MGH研修学习（访问学者）

所在团队及任职情况：

辽宁省普通高等学校本科教学名师（2019）

辽宁省优秀科技工作者（2020）

中国医科大学优秀博士学位论文指导教师（2022）

所在平台情况：