1.内皮细胞膜SNHG20-FABP5互作调控DHA脂肪酸跨血脑屏障转运促进神经血管单元损伤修复的机制，国自然面上项目，32371207，主持，50万，2024年01月至 2027年 12月；

2. SNHG12结合Occludin抑制其泛素化维系脑缺血应激损伤中血脑屏障结构稳态的研究，国自然青年项目，31900826，主持，24万，：2020年01月至 2022年 12月。

(1) Yuan Li; Jia-Yi Wei; Hui Liu; Kang-Ji Wang; Sheng-Nan Jin; Zheng-Kang Su; Hui-Jie Wang; Jun-Xiu Shi; Bo Li; De-Shu Shang; Wen-Gang Fang; Xiao-Xue Qin; Wei-Dong Zhao; Yu-Hua Chen ; An oxygen-adaptive interaction between SNHG12 and occludin maintains blood-brain barrier integrity, Cell Reports, 2022, 39(2): 110656 (中科院一区期刊论文)

(2) Yun-Hua Zhao, Yu Liang, Kang-Ji Wang, Sheng-Nan Jin, Xiao-Meng Yu, Qian Zhang, Jia-Yi Wei, Hui Liu, Wen-Gang Fang, Wei-Dong Zhao, Yuan Li^*, Yu-Hua Chen*. Endothelial lincRNA-p21 alleviates cerebral ischemia/reperfusion injury by maintaining blood-brain barrier integrity. J Cereb Blood Flow Metab. 2024，271678X241248907(中科院二区期刊论文).

(3) Hui Liu; Jia-yi Wei; Yuan Li; Meng Ban; Qi Sun; Hui-Jie Wang; Dan Zhao; Pai-Ge Tong; Li Wang; Kang-Ji Wang; Jin-Li Yue; Hong-Yan Zhang; Wen-Gang Fang; Dong-Xin Liu; De-Shu Shang; Bo Li; Ya-Ping Jin; Liu Cao; Wei-Dong Zhao; Yu-Hua Chen ; Endothelial depletion of Atg7 triggers astrocyte-microvascular disassociation at blood-brain barrier, J Cell Biol. 2023 May 1;222(5):e202103098. (中科院一区期刊论文)

(4) Shi-Yu Tang; Dong-Xin Liu; Yuan Li; Kang-Ji Wang; Xia-Fei Wang; Zheng-Kang Su; Wen-Gang Fang; Xiao-Xue Qin; Jia-Yi Wei; Wei-Dong Zhao; Yu-Hua Chen ; Caspr1 Facilitates sAPPα Production by Regulating α-Secretase ADAM9 in Brain Endothelial Cells, Frontiers in Molecular Neuroscience, 2020, 13: 23 (中科院二区期刊论文)

(5) Li, Yuan; Li, Yan; Huang, Shengkai; He, Kun; Zhao, Mei; Lin, Hong; Li, Dongdong; Qian, Jiaming; Zhou, Caihong; Chen, Yuhua; Huang, Changzhi ; Long non-coding RNA growth arrest specific transcript 5 acts as a tumour suppressor in colorectal cancer by inhibiting interleukin-10 and vascular endothelial growth factor expression., Oncotarget, 2017, 8(8): 13690-13702 (中科院二区期刊论文)

(6) Li, Yuan; Huang, Shengkai; Li, Yan; Zhang, Weilong; He, Kun; Zhao, Mei; Lin, Hong; Li, Dongdong; Zhang, Honggang; Zheng, Zhaoxu; Huang, Changzhi ; Decreased expression of LncRNA SLC25A25-AS1 promotes proliferation, chemoresistance, and EMT in colorectal cancer cells., Tumor Biology, 2016, 37(10): 14205-14215 (中科院二区期刊论文)

(7) Li Yuan; Li Yan; Huang Changzhi ; Circulating miRNAs Incresaing the Risk of Cancer, ELSEVIER, ISBN:978-0-12-811022-5, 2017 (外文学术专著)

沈阳市高层次人才拔尖人才，中国医科大学高层次青年人才

博士期间获“国家留学基金委-公派留学项目”支持，赴美国耶鲁大学、范德堡大学留学一年。

发育细胞生物学教研室副主任

教育部/卫生部重点实验室